Microbial processes require fermentors with powerful mixing, extensive. Xcellerex xdr 500 mo is a singleuse stirredtank fermentor intended for microbial cultures of up to 500 l working volume. The xdr 50 mo fermentor is part of xcellerex scalable, singleuse bioreactor family for working volumes ranging from 4. Xcellerex xdr 50 singleuse stirredtank bioreactors. See the following table for electrical specification. Xcellerex xdr 10 singleuse stirredtank bioreactor cytiva. A wide range of culturing volume of each model allows scaleup of cell culturing from 4. The bioreactors feature stainless steel dimpled jacketed kettle with multiple zones supporting a turndown ratio of 5. Xdr singleuse bioreactor systems are available with maximum working volumes of 200l xdr 200, 500l xdr 500, 1,000l xdr and 2,000l xdr 2000.
Xdr systems are available with working volumes of 50, 200, 500, 1,000 and 2,000 liters. The labels on the system and information regarding recycling are also described. Xcellerex xdr cell culture bioreactor systems, ge healthcare, ka686051118df, 2018. Try this xcellerex bioreactor get this bioprocess toolkit. Cytiva launches xcellerex automated perfusion system for more.
Xcellerex xduo100, xduo200, xduo500, xduo 25 filtration e. After initial definition of optimal basal media, eight different cell boost supplements were screened, optimized, and tested in four consecutive steps using doe and smallscale semicontinuous perfusion models. The results support use of the xdr fermentors as seed train or production bioreactors, allowing a flexible setup of fermentors in different scales and operating environments. Sep 16, 2020 cytiva is introducing the xcellerex automated perfusion system aps for continuous manufacturing. Xcellerex xdr50 mo ge healthcare life sciences biopharma. Xcellerex xdr50 to 2000 bioreactor systems operating instructions 29064643 aa. The xcellerex xdr bioreactor product line offers the benefits. Whenever this manual discusses the function of a button, please assume this it is initiated by a single left mouse click. Like the xdr cell culture line of stirredtank bioreactors, the tight relationship between equipment and consumables makes the xdr fermentation systems suitable for scaleup or scaleout, in both gmp and fig 1.
Ge healthcare xdr50 xdr50, xcellerex singleuse bioreactor. The singleuse xcellerex xdr 50 mo stirredtank fermentor system is a purposebuilt 50 l stirredtank system for growth of microbial cultures fig 1. Xcellerex xdr 10 rocker finesse 10, 20, 50 ge wave 10, 20, 50 g3lite singleuse thermo scientific hyperforma sub 50, 100, 250, 500, 2000 millipore mobius cellready 50, 200 g3pro g3flex singleuse thermo scientific hyperforma sub 50, 100, 250, 500, 2000 xcellerex xdr 50, 200, 500, 2000 atmi padreactor. Its available in single, twin, triple, and quad vessel configurations. Xcellerex xdr singleuse bioreactor is a fullyintegrated system with a capacity to demonstrate proven stirred tank performance for a host of cell lines.
Contact a supplier or the parent company directly to get a quote or to find out a price or your closest point of sale. We collect information from you when you fill out our contact form. Jun 29, 2012 in any application, the xdr 10s power and flexibility minimize the number of required runs to save time, work, and costs. Cells are recovered without the need for additional pump skid. Equipnet carries a variety of xcellerex bioreactors in our inventory, including twin 50l single use bioreactors with 1 controllers, 200l singleuse bioreactors, 200 disposable bag bioreactors. Xcellerex xdr singleuse bioreactor systems provide scalable and robust stirredtank performance for up to 2000 l in both cgmp and noncgmp environments. Standard exposure is 33%50% of dspeed film exposure, or equivalent to e speed film exposure. The xcellerex xdr bioreactor product line offers the benefits of single. Jun 15, 2012 as are all xdr singleuse bioreactors, the xdr 10 is an integral component of the xcellerex flexfactory modular biomanufacturing platform that leverages singleuse technology and advanced process. Xdr singleuse bioreactors from xcellerex are fullyintegrated, fullycharacterized systems designed for gmp clinical and commercial production. The system consists of a cabinet constructed with 316l grade. Xcellerex xdr 500 mo singleuse fermentor for microbial processes jozsef vasi, andreas castan and sandeep kristiansson ge healthcare biosciences ab, bjorkgatan 30, 75184 uppsala, sweden.
Xcellerex introduces xdr10 singleuse bioreactor for. Xcellerex xdr single use bioreactors these bioreactors are singleuse bioreactors with a built in impeller. Sparging flexibility offers excellent adaptability to a broad range of cell lines. The systems automation capabilities include automated filter switching, liquid management and cell bleed, which reduces risk for human error and increases process robustness. Users who are subscribers to xdr s software support program may contact xdr at 888 xdr xray 8889379729 to schedule an appointment with a technician to help your office establish the proper exposure settings for your xray generator. This increases output compared to traditional batch or fed batch methods, yet perfusion processes still involve substantial manual work and risk. Xcellerex is a supplier of manufacturing technologies, developing and producing biomanufacturing systems and productionscale bioreactors. Xcellerex aps system integrates with cytivas xcellerex xdr bioreactors for continuous upstream bioprocessing operations. Xcellerex xdr cell culture suite aktaready and readytoprocess prepacked columns 20 2012 2014 2015 billingham, uk driven by the industry need for cgmp mammalian cell culture biomanufacturing capacity four successful capacity expansion projects on two continents creating the uks first fully singleuse biomanufacturing facility. Xcellerex xdr 50, xdr 200, xdr 500, xdr, xdr 2000 9 c. Modular design enables configurability and provides added flexibility. Designed for scalability and robustness, the xdr bioreactor systems provide the performance and flexibility needed from process development to large. Xcellerex xduo 2500 mixer is a robust, versatile, and easytouse 2500 l singleuse mixer for both upstream and downstream applications. Fits to your existing pcs with your pcs servo motor driving.
Xcellerex singleuse mixers xcellerex xdr cell culture suite aktareadypurification system xcellerex xdr 2000l bioreactor added research triangle park, us research triangle park, us 2000 l project xcellerex xdr 2000l bioreactor added billingham, uk ongoing partnership. Xcellerex xdr200l singleuse bioreactor with controller. The bioreactors xcellerex xdr from 50 to 2000l include a mixing vessel and disposable cups. Xcellerex xdr 500 mo microbial fermentor ge healthcare. Process design for an all singleuse manufacturing facility. Xcellerex automated perfusion system provides a singleuse. Engineering characterization of the singleuse xcellerex xdr 2000 stirredtank bioreactor system, 29243481 edition ab, 2017 6. The biomanufacturing solutions transform the speed and economics of producing therapeutic proteins, including biosimilars and vaccines.
Xdr provides ultra clear, high contrast filmlike images as well as specialized soft tissue and hard tissue enhancement functions that provide you with the superior. Sep 28, 2020 xcellerex aps system integrates with cytivas xcellerex xdr bioreactors for continuous upstream bioprocessing operations. This video is a listing for a used 2009 ge xcellerex xdr 500 stainless steel bioreactor. Bia cytiva launches xcellerex automated perfusion system.
Scaling strategy for moving mab process from microscale to. In addition, it has an automated cell harvest function. Xcellerex aps integrates with three bioreactors in the xcellerex xdr family 50, 200, and 500 l to enable perfusion capability. This chapter describes safety precautions and emergency shutdown procedures for xdm quad singleuse mixer. The xcellerex aps provides a solution to the challenges of traditional perfusion culture systems by integrating automation and limiting manual operations. The xcellerex aps system is designed for operation with xcellerex xdr bioreactors of 50, 200 and 500 litres. System includes the xcpii and 500 liter vessel, along with control. The xdr 10 is smallest bioreactor in xcellerex s industryleading xdr product line. Xcellerex xdr cell culture bioreactor systems cytiva. Xcellerex has a high quality of bioreactors, including bioprocessing bioreactors, stirredtank bioreactor systems, bioreactors for cell culture, and more. Its proprietary products offer significant advantages such as faster. The xdr bioreactor systems are designed for use in environments that require 21 cfr part 11 and gamp 5.
Xcellerex xdr10 benchtop bioreactor system operating instructions 290645 86 aa. Xcellerex xdr singleuse bioreactor systems provide scalable and robust stirred tank performance for up to 2000 l in both cgmp and noncgmp environments. The systems are delivered with an operating manual, system specification. Xcellerex xdm quad singleuse mixer operating instructions manual. The singleuse xcellerex xdr 10 is a flexible, stirredtank bioreactor system suitable for use in process development, smallscale production, and process troubleshooting.
Its the first and only bagtype singleuse bioreactor versatile enough to handle volumes from 4 l to 10 l. As are all xdr singleuse bioreactors, the xdr 10 is an integral component of the xcellerex flexfactory modular biomanufacturing platform that leverages singleuse technology and advanced process automation. The singleuse xcellerex xdr50 mo stirredtank fermentor system is a purpose built 50 l stirredtank system for growth of microbial cultures fig 1. Cytiva launches automated perfusion system for biotherapeutics. All xcellerex systems, with the exception of the xdr 10 will be delivered with the flying leads, that is. Laboratory bioreactor xcellerex xdr mo ge healthcare life. Singleuse manufacturing design and implementation ge healthcare. Xcellerex xdr 200l singleuse bioreactor with controller. Ge healthcare xcellerex xdr10 master max bioreactor. Xcellerex xdr 500 mo microbial fermentor ge healthcare on vimeo. The bioreactors xcellerex xdr singleuse provide guaranteed upward production of biosimilars. Xcellerex xdr50 to 2000 bioreactor systems operating instructions. Customized 5,7 liter bactovessel singleusefermenter suf being a unique scaling down of the xcellerex xdr 50 bag with a factor 10. Ge healthcare xcellerex xdr 10 master max bioreactor.
Together, xdr bioreactors, the xcellerex team and our bioprocess toolkit. The lab world group has written this privacy policy to establish our pledge to your privacy. Xcellerex xdr 10 benchtop bioreactor system operating instructions 29064586 aa. The novel perfusion control strategy with accurate process control enhances reproducibility, predictability, and reliability. Ge healthcare xdr10 xdr10 xcellerex singleuse bioreactor. When ordering or registering on our site, as appropriate, you may be asked to enter your.
All xcellerex systems, with the exception of the xdr10 will be delivered with the flying leads, that is. Xcellerex xdr 50 to 2000 bioreactor systems operating instructions 29064643 aa. Xdr500 mosingleuse fermentor for microbial processes. Xcellerex xdm quad singleuse mixer operating instructions. Adaptable to a variety of molecules, applications, or multidrug processes. Disposable bioreactor holland applied technologies. Along with our endtoend flexible manufacturing solutions, automation technology and trusted expertise, we have introduced xcellerex aps to support the industrys journey to integrated continuous manufacturing. This system was removed from a major biopharma facility, it was in use just prior to removal. The system design of xdr stirredtank bioreactors enables easy scaling and facilitates the achievement of a robust, final manufacturingscale process. Xcellerex xdr 50to2000 bioreactorsystems operatinginstructions originalinstructions. Xcellerex xdr 50 to 2000 singleuse stirredtank bioreactors. In cell cultivation using perfusion, media is continuously fed and product harvested.
Xcellerex xdr 500 mo singleuse fermentor system the singleuse xdr 500 mo fermentor system is a 500 l working volume v w system specifically designed for growth of microbial cultures fig 1. Xcellerex xdr singleuse bioreactor systems provide scalable and robust stirredtank performance for up to 50. Find out all of the information about the ge healthcare life sciences product. The flexibility and scalability of the system further increases its value in providing solutions across several different perfusion applications. The systems are delivered with an operating manual, system specification, drawings to support qualification, and major component documentation.
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